Anti-tumor effects of valproate zinc complexes on a lung cancer cell line

The ternary complexes containing Zn +2 , valproate, and 2,2′-bipyridine (complex 1 ) nicotinamide 2 showed anti-tumor effect on a lung cancer cell line. • Complexes cause significant reduction in growth of human epithelial cells. Complex induces apoptosis but is less selective than 2. reduces the frequency cells S phase cycle. Lung one most common types worldwide development new treatment strategies needed. Valproate exhibits anti-cancer properties has been studied as candidate for therapy. Novel treatments with synthesized coordination valproate bioisosteres are promising, they often more effective organic molecules. We evaluated anti-tumoral effects two or Both exerted 50% viability (A549), indicating that improves cytotoxic valproate. increased apoptotic 6-fold compared to vehicle, it was tumor complex . reduced at rates similar (from 10.2% control 0% both valproate). Our data highlighted potential activity valproate-Zn their proptotypes drugs.